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KMID : 0370220060500060398
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Yakhak Hoeji
2006 Volume.50 No. 6 p.398 ~ p.402
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Synthesis of 2-Substiruted Flavone Derivatives
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Dan On-Wha
Im Chae-Uk
Kim Soo-Jin
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Abstract
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Flavone was found to inhibit tyrosinase and reduce synthesis of melanin to show skin-lightening effect. With the hope of identifying-lightening flavones, we synthesized flavone analogs. Substituted benzoic acids (1) were treated with oxalyl chloride in DMF to yield benzoyl chlorides (2), which were reacted with 2-hydroxyacetophenones (3) to afford 2-benzoyloxyacetophenones (4). These acetophenones (4) were converted into 1,3-diketones (5) with base and then treated with acid to give flavone derivatives (6).
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KEYWORD
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flavone, tyrosinase inhibitors
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